Rapid impairment of sensorimotor gating by stress-level cortisol
نویسندگان
چکیده
منابع مشابه
Sensorimotor gating in larval zebrafish.
Control of behavior in the natural environment where sensory stimuli are abundant requires superfluous information to be ignored. In part, this is achieved through selective transmission, or gating of signals to motor systems. A quantitative and clinically important measure of sensorimotor gating is prepulse inhibition (PPI) of the startle response, impairments in which have been demonstrated i...
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BACKGROUND Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop these disorders, the mechanisms driving the sex specificity of disease vulnerab...
متن کاملSensorimotor gating deficits and hypofrontality in schizophrenia.
Patients with schizophrenia exhibit (a) deficient sensorimotor gating as indexed by impaired prepulse inhibition (PPI) of the startle eyeblink reflex suggesting abnormal automatic information processing and (b) abnormal attentional modulation of PPI suggesting impaired controlled information processing. Here we test the hypothesis of deficient attentional modulation of PPI in schizophrenia as a...
متن کاملSensorimotor Gating: Startle Submits to Presynaptic Inhibition
Prepulse inhibition is a type of sensorimotor gating that is disrupted in some neuropsychiatric disorders. Its cellular basis has eluded investigators but now, using a molluscan model system, a cellular mechanism has been established.
متن کاملDETERMINATION OF SERUM CORTISOL LEVEL BY A DIREC T ENZYME IMMUNOASSAY USING PENICILLINASE AS LABEL
Serum cortisol level was measured by an enzyme immunoassay (EIA) using the enzyme penicillinase as a label without prior extraction and purification. Polyclonal antibodies were raised against cortisol-3-ortho-carboxymethyl-oxime (cortisol-3-0-CMO) conjugated to bovine serum albumin (BSA). This antibody showed a very low cross-reactivity with structurally related steroids (3.7% for corticos...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2009
ISSN: 1662-5153
DOI: 10.3389/conf.neuro.08.2009.09.277